Regenerative cell therapy for epilepsy

Health News
Tags :
Health News
Share This :


Regenerative cell therapy for epilepsy
Credit: Cell Stem Cell (2023). DOI: 10.1016/j.stem.2023.08.013

Together with colleagues, veterinarian and neuroscientist Sonja Bröer has researched how regenerative cell therapies can contribute to curing or alleviating epilepsy. The work was carried out at biotechnology start-up Neurona Therapeutics, Inc. in San Francisco, where Bröer led a team in preclinical research, before she moved to Freie Universität Berlin.

The company is developing a cell therapy (NRTX-1001) for treatment-resistant epilepsy and has now published the results from preclinical studies in Cell Stem Cell. Based on these data, the cell therapy is now being evaluated in human patients as part of an ongoing phase 1/2 clinical trial. On October 6, 2023, Bröer will present both the preclinical and the first clinical data at the Einstein Center for Neurosciences’ Berlin Neuroscience Meeting.

Approximately 50 million people worldwide suffer from epilepsy; in about one-third of patients, epileptic seizures do not respond to drug treatment, reducing patients’ quality of life as well as their life expectancy. Epilepsy occurs when excessive electrical discharges occur in nerve cells of the brain.

The neurotransmitter gamma-aminobutyric acid (GABA) can block this overexcitation. However, the nerve cells that secrete this neurotransmitter can degenerate in patients with epilepsy, creating an imbalance between inhibition and excitation in the brain that is thought to pave the way for epileptic seizure activity.

In their recent publication in Cell Stem Cell, Bröer and her colleagues report on the transplantation of inhibitory GABA-secreting neurons that can potentially restore the balance in the brain and suppress epileptic seizures. Developing and characterizing such a cell therapy could provide a breakthrough alternative for patients with treatment-resistant seizures.

Developed by Neurona Therapeutics, cell therapy NRTX-1001 is derived from a human embryonic stem cell line and differentiated into inhibitory neurons. Administering NRTX-1001 into a mouse model of chronic epilepsy resulted in long-lasting and reproducible seizure suppression, with most animals becoming completely seizure-free.

The transplanted inhibitory neurons distributed throughout the brain and integrated themselves into the host’s existing neuronal network. The cells survived long-term and also reduced other pathological side effects of epilepsy, such as scarring in the brain, which also occurs in human patients.

These disease-modifying effects were dose-dependent. No adverse effects were observed. These results support an ongoing phase 1/2 clinical trial (NCT05135091) for drug-resistant epilepsy. If approved, this would be the first cell therapy for epilepsy worldwide and an alternative that could transform the lives of millions of patients suffering from treatment-resistant seizures.

More information:
Marina Bershteyn et al, Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy, Cell Stem Cell (2023). DOI: 10.1016/j.stem.2023.08.013

Citation:
Regenerative cell therapy for epilepsy (2023, October 6)
retrieved 6 October 2023
from https://medicalxpress.com/news/2023-10-regenerative-cell-therapy-epilepsy.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.





Source link

Leave a Reply

Your email address will not be published. Required fields are marked *

Popular News Posts

Categories

Our Exclusive Products

Our Store

Our mission is simple, offer quality products that make our customers lives better at a reasonable price, while ensuring a hassle-free shopping experience. This means that before we bring a product to market, we test it to ensure that it meets our high-level quality standards. Our customer service team understand our products and can answer most every product related question quickly and efficiently. We strive everyday to meet and exceed our customers’ expectations of quality and support! Should we ever fail to meet this expectation – contact us and we will make it right!

Our Value: We are proud of our product and accomplishments, but we typically don’t shout it from the rooftop. Instead, we prefer to let our product and customers do the talking. Our core values can be recognized in our product. The qualities we strive for include:

Pragmatism: We design simple, useful solutions for common needs
Quality: From design to final product, we strive for durable solutions that work
Originality: Creativity and innovation are what makes our product unique
Design: Our minimalist and bold design language focuses on functionality and simplicity that is timeless

0 +

Top Rated Products

0 +

Happy Customers