Allergy study on ‘dirty’ mice challenges the hygiene hypothesis

Health News
Tags :
Health News
Share This :


mice
Credit: CC0 Public Domain

The notion that some level of microbial exposure might reduce our risk of developing allergies has arisen over the last few decades and has been termed the hygiene hypothesis.

Now, an article published in Science Immunology by researchers from Karolinska Institutet challenges this hypothesis by showing that mice with high infectious exposures from birth have the same, if not an even greater ability to develop allergic immune responses than “clean” laboratory mice.

How microbes may prevent allergy has been a topic of great interest in recent times. Studies have suggested that certain infections might reduce the production of inflammatory antibodies to allergens and alter the behavior of T cells involved in allergies. It has also been suggested that good bacteria in our intestines may be able to switch off inflammation in other parts of our body.

Robust allergic responses

Researchers have now compared the allergic immune response in “dirty” wildling mice to those of typical clean laboratory mice. They found very little evidence that the antibody response was altered or that the function of T cells changed in a meaningful way. Nor did anti-inflammatory responses evoked by good gut bacteria appear to be capable of switching off the allergic immune response. On the contrary, wildling mice developed robust signs of pathological inflammation and allergic responses when exposed to allergens.

“This was a little unexpected but suggests that it’s not as simple as saying, ‘dirty lifestyles will stop allergies while clean lifestyles may set them off.’ There are probably very specific contexts where this is true, but it is perhaps not a general rule,” says Jonathan Coquet, co-author of the study and Associate Professor at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet in Sweden.

More like the human immune system

The wildling mice are genetically identical to clean laboratory mice but are housed under seminatural conditions and have rich microbial exposures from birth.

“The immune systems of wildling mice better represent the human immune system and so we hope that they can bring us closer to the truth of how microbes act upon the body,” says Jonathan Coquet.

The findings contribute to our general understanding of how allergies may arise and may also have clinical implications. In clinical trial settings, researchers and clinicians have recently made attempts to treat patients suffering from inflammatory diseases with experimental infections.

For example, infecting people with worms or performing fecal transplantations has been proposed as a tool to combat inflammatory diseases. Newborns delivered through C-section, have had maternal fecal transplantation and bacterial supplementation with the aim of promoting good bacteria in the baby’s gut and the child’s future health.

Can provide important insights

“This field of research can provide important insights into how infections and microbes can be used to facilitate health, but it is still in its infancy. Our study is a reminder that general and broad exposures to microbes may not have the clear beneficial effects that we wish them to have,” says Susanne Nylén, co-author of the study and Associate Professor at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet.

The work was led by Junjie Ma and Egon Urgard, researchers in Jonathan Coquet’s group, and done in close collaboration with Professor Stephan Rosshart at University Medical Center Freiburg in Germany and Susanne Nylén (MTC).

Several other research groups at Karolinska Institutet and elsewhere also contributed to this work, including the teams of Assistant professors Itziar Martinez Gonzalez and Juan Du (both at the Department of Microbiology, Tumor and Cell Biology, MTC).

More information:
Junjie ma et al, Laboratory mice with a wild microbiota generate strong allergic immune responses, Science Immunology (2023). DOI: 10.1126/sciimmunol.adf7702. www.science.org/doi/10.1126/sciimmunol.adf7702

Citation:
Allergy study on ‘dirty’ mice challenges the hygiene hypothesis (2023, September 29)
retrieved 29 September 2023
from https://medicalxpress.com/news/2023-09-allergy-dirty-mice-hygiene-hypothesis.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.





Source link

Leave a Reply

Your email address will not be published. Required fields are marked *

Popular News Posts

Categories

Our Exclusive Products

Our Store

Our mission is simple, offer quality products that make our customers lives better at a reasonable price, while ensuring a hassle-free shopping experience. This means that before we bring a product to market, we test it to ensure that it meets our high-level quality standards. Our customer service team understand our products and can answer most every product related question quickly and efficiently. We strive everyday to meet and exceed our customers’ expectations of quality and support! Should we ever fail to meet this expectation – contact us and we will make it right!

Our Value: We are proud of our product and accomplishments, but we typically don’t shout it from the rooftop. Instead, we prefer to let our product and customers do the talking. Our core values can be recognized in our product. The qualities we strive for include:

Pragmatism: We design simple, useful solutions for common needs
Quality: From design to final product, we strive for durable solutions that work
Originality: Creativity and innovation are what makes our product unique
Design: Our minimalist and bold design language focuses on functionality and simplicity that is timeless

0 +

Top Rated Products

0 +

Happy Customers