How periods may affect sensitivity to insulin

Health News
Tags :
Health News
Share This :

How periods may affect sensitivity to insulin
Credit: Annika Gordon/Unsplash

The sensitivity of the brain to insulin may be modulated by menstrual cycle phase, a paper published in Nature Metabolism suggests. The findings are based on a randomized clinical trial involving 11 women.

Previous research has demonstrated that the brain is sensitive to insulin and that insulin affects specialized neurons in the brain. Insulin has been shown to affect the modulation of eating behaviors and whole-body metabolism. It has also been suggested that there may be sex differences in the regulation of whole-body metabolism by brain insulin, however this research has mostly been conducted in men.

Martin Heni and colleagues investigated the influence of brain insulin activity in 11 women during both the follicular (first day of cycle to ovulation) and the luteal phase (post-ovulation to last day of cycle) of the menstrual cycle. The women underwent four hyperinsulinemic-euglycemic clamps, a procedure that allowed for the measuring of insulin sensitivity. Brain insulin activity was measured via intranasal insulin administration and compared to a non-insulin placebo spray.

The authors found that during the follicular phase of the menstrual cycle, there was increased insulin sensitivity in the brain, which was not observed during the luteal phase. They conducted functional MRI scans in an additional 15 women to assess insulin sensitivity in a specific brain region, the hypothalamus, and observed similar insulin sensitivity during the follicular but not luteal phase of the menstrual cycle.

The authors suggest that the brain’s sensitivity to insulin is higher during the follicular phase of the menstrual cycle, and that brain insulin resistance could contribute to whole-body insulin resistance in the luteal phase.

In an accompanying News & Views article in the same journal issue, Nils Kroemer writes, “The current study provides evidence for the crucial role of insulin in the brain in regulating whole-body insulin sensitivity during the menstrual cycle.

“Flanked by the observed increase in hypothalamic insulin sensitivity, it is plausible that altered hypothalamic projections to motivational circuits could help to explain associated changes in body weight regulation, appetite and food craving that are often reported in a premenstrual (that is, late luteal) phase when central insulin sensitivity is lower.”

More information:
Julia Hummel et al, Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase, Nature Metabolism (2023). DOI: 10.1038/s42255-023-00869-w

Nils B. Kroemer, Metabolic tuning during the menstrual cycle, Nature Metabolism (2023). DOI: 10.1038/s42255-023-00867-y

Provided by
Eberhard Karls University

How periods may affect sensitivity to insulin (2023, September 24)
retrieved 24 September 2023

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

Source link

Leave a Reply

Your email address will not be published. Required fields are marked *

Popular News Posts


Our Exclusive Products

Our Store

Our mission is simple, offer quality products that make our customers lives better at a reasonable price, while ensuring a hassle-free shopping experience. This means that before we bring a product to market, we test it to ensure that it meets our high-level quality standards. Our customer service team understand our products and can answer most every product related question quickly and efficiently. We strive everyday to meet and exceed our customers’ expectations of quality and support! Should we ever fail to meet this expectation – contact us and we will make it right!

Our Value: We are proud of our product and accomplishments, but we typically don’t shout it from the rooftop. Instead, we prefer to let our product and customers do the talking. Our core values can be recognized in our product. The qualities we strive for include:

Pragmatism: We design simple, useful solutions for common needs
Quality: From design to final product, we strive for durable solutions that work
Originality: Creativity and innovation are what makes our product unique
Design: Our minimalist and bold design language focuses on functionality and simplicity that is timeless

0 +

Top Rated Products

0 +

Happy Customers