Hydrogen sulfide could be the key to a revolutionary anti-aging treatment

Anti-Aging Medicine
Tags :
Anti-Aging Medicine
Share This :


EXETER, United Kingdom — British researchers have discovered potential therapies to prolong active, healthy lives. Utilizing drugs that release minuscule amounts of the gas hydrogen sulfide (H2S), scientists at the University of Exeter found that this anti-aging therapeutic technique works when specifically targeted within cells.

Through experiments on adult worms, the team found that by using small doses of H2S specifically to target cell mitochondria using a molecule named AP39, they could significantly enhance the health and activity of the worms as they grew older. Mitochondria are often dubbed the “powerhouse” of cells because they produce energy for them.

Hydrogen sulfide image
Hydrogen sulfide image. (credit: University of Exeter)

Mitochondrial dysfunction is linked with a number of age-related conditions, such as natural aging, neurodegenerative diseases like Parkinson’s and Alzheimer’s, muscular dystrophy, and primary mitochondrial diseases.

Researchers discovered a set of proteins responsible for regulating gene expression in aging (transcription factors). These proteins were specifically targeted by H2S, opening up potential avenues for therapies addressing aging and muscle-related conditions.

“Worms are a powerful genetic tool to study human health and disease and offer a strong platform to quickly identify new potential therapeutics,” says Tim Etheridge, the study’s senior author and professor at the University of Exeter, in a university release. “Diseases related to aging take a huge toll on society. Our results indicate that H2S, administered to specific parts of the cell in tiny quantities, could one day be used to help people live healthier for longer.”

Researchers previously explored targeting skeletal muscle with H2S in worms. This new publication showcases the first application of this method to natural aging.

MitoRx Therapeutics, a spin-out company of the University of Exeter, has been granted the rights to the foundational technology. The company is currently developing advanced compounds as potential medicines to tackle age-related diseases, including Huntington’s disease and childhood conditions like muscular dystrophy.

“This study is not about extending life – it’s about living healthier lives well into older age. This could have huge benefits to society,” says Matt Whiteman, study co-author and professor at the University of Exeter. “We’re excited to see this research move to the next stages over the coming years, and hope it will one day form the basis of new treatments which we have the potential to develop with MitoRx.”

Even though the worms still died, later than normally expected, researchers note they “died very active and with a young physiology.”

The study is published in the journal Proceedings of the National Academy of Sciences.

You might also be interested in: 

YouTube video



Source link

Leave a Reply

Your email address will not be published. Required fields are marked *

Popular News Posts

Categories

Our Exclusive Products

Our Store

Our mission is simple, offer quality products that make our customers lives better at a reasonable price, while ensuring a hassle-free shopping experience. This means that before we bring a product to market, we test it to ensure that it meets our high-level quality standards. Our customer service team understand our products and can answer most every product related question quickly and efficiently. We strive everyday to meet and exceed our customers’ expectations of quality and support! Should we ever fail to meet this expectation – contact us and we will make it right!

Our Value: We are proud of our product and accomplishments, but we typically don’t shout it from the rooftop. Instead, we prefer to let our product and customers do the talking. Our core values can be recognized in our product. The qualities we strive for include:

Pragmatism: We design simple, useful solutions for common needs
Quality: From design to final product, we strive for durable solutions that work
Originality: Creativity and innovation are what makes our product unique
Design: Our minimalist and bold design language focuses on functionality and simplicity that is timeless

0 +

Top Rated Products

0 +

Happy Customers