Spermidine: Benefits and Our Top Ten Picks!

Anti-Aging Medicine
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Anti-Aging Medicine
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An intriguing polyamine has been gaining significant attention for its potential to unlock a treasure trove of benefits: spermidine. This unassuming yet powerful compound is found abundantly in various foods, boasting antioxidant and anti-inflammatory properties that have captured the interest of researchers and health enthusiasts alike. Notably, it holds the unique ability to shield our DNA from oxidative damage, a fundamental mechanism in the aging process.

From maintaining cellular integrity to supporting overall well-being, spermidine’s influence extends across various aspects of health. The pathway to harnessing these benefits is paved by a diet with spermidine-rich foods—a natural approach that harmonizes nutrition and longevity. For those seeking to optimize their intake, supplements derived from wholesome sources like wheat germ offer an alternative route to bolstering spermidine levels.

As we navigate the landscape of nutritional supplements, a prudent approach is paramount. While the existing body of research presents no cause for alarm regarding the consumption of spermidine, it’s always wise to tread with caution. Consulting a medical professional before incorporating any new supplement regimen is a cornerstone of responsible health management.

Spermidine offers a host of benefits. First and foremost, it is thought to be “anti-aging” with the potential to prevent age-related diseases.

  • Cardiovascular Health – The heart, the epicenter of vitality, finds an ally in spermidine. Emerging research suggests that this polyamine could play a pivotal role in the fight against cardiovascular ailments. By inhibiting the development of atherosclerosis—a condition characterized by the accumulation of plaque in arterial walls—spermidine showcases its potential to protect against a major contributor to heart disease. Moreover, its influence extends to clot prevention, reducing the risk of dangerous blood clots that can lead to heart attacks or strokes. Lowering blood pressure adds another feather to spermidine’s cardiovascular cap, potentially contributing to a healthier circulatory system.
  • Neurological Health – Through its capacity to stimulate autophagy—a cellular process that clears out damaged components—spermidine shields nerve cells from harm, potentially safeguarding against neurological diseases. The implications are far-reaching, as this polyamine might assist in reducing cognitive impairment and memory loss. Such neuroprotective attributes offer a glimmer of hope for maintaining cognitive vitality as we age.
  • Metabolic Health – Spermidine appears to wield the power to lower blood sugar levels, a promising discovery for individuals grappling with diabetes or seeking to stabilize their glucose metabolism. Furthermore, spermidine’s potential to enhance insulin production could potentially benefit those with insulin resistance. By playing a role in glucose regulation, spermidine becomes an intriguing contender in the pursuit of metabolic equilibrium.
  • Inflammation & Immunity – Inflammation, the silent accomplice to numerous health ailments, encounters resistance in the form of spermidine. Spermidine has shown promise in preventing the loss of certain memory cells, potentially contributing to the preservation of cognitive function. Moreover, its ability to combat viruses suggests a role in bolstering immune responses.

1. Longevity Labs

spermidineLIFE 800mg Natural Supplement, Plant-Based, Wheat Germ Extract with High Spermidine Content and Zinc for Cell Renewal
Longevity Labs SpermidineLife Supplement

This vegan-friendly spermidine supplement from Longevity Labs is made from wheat germ. Using a proprietary solvent-less, vegan, all-natural extraction process it boasts the highest quality ingredients. It costs $62.10 for 60 capsules, which is on the pricier side for these supplements.

With 4.2 stars on Amazon, the reviews are pretty good. One user said, “I first came across Spermidine after having my hair fall out in clumps, and googling options. I had been diagnosed with a malabsorption syndrome and auto immune fair up…
I decided to try it as it would either stop the hair loss or not. I am not a supplement taker but I was desperate to stop the hair loss. I also had no expectation for it to help my other issues but I was wrong.
I took 4 tablets per day. Within a month the hair loss had stopped and my hair started growing in thicker all over. This was a physically dramatic, measurable change. I could see the bald spots filling in and a thicker fringe of hair about 1/4 inch long all over my scalp in places where it had been thinner.
The other improvement was energy and mental clarity. I was normally dog tired by 3:00 every day and showing signs of auto immune issues. This supplement definitely made an improvement. I know because I stopped taking it after 6 months and my health issues started to creep back. So for me, I feel I’ve tested it both ways and I’m convinced it makes a difference.”

2. Vitauthority

Enhanced Absorption Pure Spermidine Supplement
Vitauthority Enhanced Absorption Pure Spermidine Supplement

Vitauthority’s Enhanced Absorption Pure Spermidine Supplement relies on strict quality measures to provide a vegan, sugar-free, non-GMO supplement. For 60 capsules, it costs $39.99.

It has high reviews, with 4.8 stars overall! Angela Bobrowski said in her review, “This is the 1st time I’m trying a Spermidine Supplement, that helps with anti-aging. Helps with my full body, that has great benefits. Great ingredients. Gets rid of old cells in exchange for new cells, that’s more efficient & perform better in my body. Gives my skin a nice glow, soft skin, sleep better, great energy, and great health benefits. I see a difference in taking these capsules. Great anti-aging supplement, that works”

3. Verso

Verso Clean Being Spermidine Dietary Supplement Capsules for Natural Cellular Clean Up, Vegan
Verso Clean Being Spermidine Supplement

Verso Clean Being Spermidine Supplement is vegan, gluten-free, and third-party lab-tested. The supplement also includes luteolin and dihydrooquercetin for similar but more effective benefits. From 120 capsules, it costs $112.31. This price is a little on the higher side, but still comparable to other spermidine supplements.

Unfortunately, the reviews on Amazon don’t seem too promising with one user saying, “Didn’t notice any difference.” However, their website tells a different story with an overall rating of 4.5 stars.

4. Peak Performance

Spermidine Supplement Ultra High Strength Standardized to 99% Spermidine Trihydrochloride. More Potent Than Wheat Germ Extract. Vegan Capsules
Peak Performance Standardized Spermidine

Peak Performance Standardized Spermidine is high strength, vegan, gluten-free, non-GMO, and made in the USA with globally sourced ingredients. It costs $23.36 for 30 capsules, which is normal for spermidine supplements.

The Peak Performance Spermidine Supplements have an overall rating of 4.2 stars. One user said, “I felt the difference immediately, my face cleared up and I even felt the boost in my immune system. My entire house got sick with the flu and surprisingly I didn’t! Not to mention I usually have a hard time swallowing pills or get extremely nauseous after taking supplements and this brand didn’t do that to me which is a big thing for me to keep buying from the same brand!”

5. Thalacy Fermented Wheat Germ Extract

Spermidine Supplements 13mg - 1300mg Wheat Germ Extract Capsules Potent Formula with Higher Spermidine Content and Zinc for Healthy Aging, Daily Immune
Thalacy Spermidine Supplement

Thalacy Fermented Wheat Germ Extract is a spermidine supplement with thirteen times the typical spermidine compared to others. It is vegan and also contains zinc for immune response. For 60 capsules it is cheaper than other spermidine supplements at $20.99.

Greg Graham said in his review, “As a 64-year-old, still having hair on my head, I do have a bald(ing) area at the crown of my head. It was slowly increasing in size. After about 60 days of beginning my regiment on these wheat germ capsules, FIRST I noticed when I would comb through my hair, I would lose significantly LESS hair in the comb. Then – in looking via the mirror – where the bald spot WAS significantly pronounced, it looked LESS pronounced.”

6. Double Wood


Spermidine Supplement (10mg of 99% Spermidine 3HCL - Third Party Tested) 120 Capsules
Double Wood Spermidine Supplement

Double Wood Spermidine Supplement is encapsulated in vegan cellulose. It claims to be 100x more potent than other supplements. For 60 pills, it costs $35.96, which is cheap compared to other similar products.

One reviewer said, “I was so pleased with this Spermidine. Within 4 weeks my skin was tighter, shinier, and had improved texture. Lotion went on smoother, and I noticed the difference when shaving.”

7. HumanX

HUMANX Spermidine+ (USA Third Party Tested) - Spermidine-Rich Wheat Germ Extract & Zinc to Activate Cellular Renewal - Non-GMO, Spermidine Capsules, vegan
HUMANX Spermidine+

With a sleek design and all-vegan capsules, HumanX Spermidine+ is a great option. It is third-party tested, non-GMO, and zinc-activated. It is not as pricey as some similar supplements as it costs $44.96 for 60 capsules.

Devin McNamara said, “When purchasing products and supplements like this I am always a little bit skeptical, but after using them for about a week or two I have noticed quite a bit of difference in my energy level. What really sold me was seeing that there are no additives like other brands may have and I am glad that I gave them a try!”

8. Neurogan

Neurogan Spermidine Supplement - 1200mg - 99% Pure 100x More Potent Than Rice & Wheat Germ Extract - for Cellular Health, Anti-Aging & Energy
Neurogan Spermidine Supplement

Made in the USA, Neurogan Spermidine Tablets promote anti-aging. They, of course, are vegan. Additionally, they are one of the cheaper supplements coming in at $29.95 for 120 tablets.

They have an overall rating of 4.8 stars. Alyssa McDorman said, “First of all I LOVE Neurogan products so I was so excited to try this. I have been taking it for a few weeks now and I do feel more energy and less brain fog. I can’t wait to see and feel the difference in the next few months!”

9. Prime Powders




Prime Powders Spermidine Capsules
Prime Powders Spermidine Capsules

Prime Powders Spermidine Capsules offer telemere Support in their all-vegan capsules. For 120 servings, it costs $33.97.

They have an overall rating of 4.6 stars. One reviewer said, “I’ve heard a lot of promising research on the supplementation of spermidine to promote autophagy and to get you to gain more consistent energy throughout the day. During the first few days of taking spermidine, I noticed a slight increase in my energy in the mornings with me feeling a lot more rested. In the late afternoons, I felt a surge of energy that helped me throughout my workouts and helped me be productive until I went to sleep.”

10. The Supermom Company

Spermidine 60 Vegetable Capsules
The Supermom Company Spermidine

Using wheat germ extract, the Supermom Company Spermidine Supplements are vegan, non-GMO, and clinically tested. For 60 vegetable capsules, they cost $37.95, which is a great price!

Overall, they have 4.5 stars on Amazon. One reviewer, named Kelsey, said “Received it about a week ago and loved it! Worth recommending to friends as well.”

Spermidine’s potential to unlock a trove of benefits, from shielding against age-related diseases to promoting overall well-being, presents an exciting opportunity for those seeking to optimize their vitality.

However, as with any venture into wellness, a cautious approach is essential. Before embarking on a spermidine regimen, it’s crucial to consult with a mental health professional or doctor to ensure that it aligns with your health profile and objectives.

For recipes using spermidine-rich foods, like wheat germ, soybeans, mushrooms, peas, nuts, and broccoli, consider downloading the Food Monster App!

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