Across successive waves of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), there was a decrease in intensive care unit (ICU) admissions across ages, while ventilatory and oxygen support varied by age, according to a study published online Aug. 21 in JAMA Pediatrics.
Yanshan Zhu, from the University of Queensland in Australia, and colleagues examined whether the dominant circulating SARS-CoV-2 VOCs were associated with differences in COVID-19 severity in hospitalized children (younger than 18 years) using data obtained from nine countries during three time frames. Timeframes (T) 1, 2, and 3 were defined to represent periods of dominance by the ancestral virus, pre-omicron VOCs, and omicron, respectively.
Data were included for 31,785 hospitalized children and adolescents. The researchers found that for children younger than 5 years, there was a reduction in ICU admission across successive SARS-CoV-2 waves (T3 versus T1: risk ratios [RRs], 0.56 and 0.61 for <6 months and 6 months to <5 years, respectively); no reduction was seen in ventilatory support or oxygen therapy. In children aged 5 years to <18 years, there were decreases in ICU admission, ventilatory support, and oxygen therapy across SARS-CoV-2 waves (T3 versus T1: RRs, 0.39, 0.37, and 0.47, respectively).
“These findings highlight the importance of considering different pediatric age groups when assessing disease severity in SARS-CoV-2,” the authors write.
Yanshan Zhu et al, International Pediatric COVID-19 Severity Over the Course of the Pandemic, JAMA Pediatrics (2023). DOI: 10.1001/jamapediatrics.2023.3117
2023 HealthDay. All rights reserved.
Pediatric ICU admissions for SARS-CoV-2 decreased across waves (2023, September 2)
retrieved 2 September 2023
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.