Younger patients with multiple myeloma can achieve durable survival

Health News
Tags :
Health News
Share This :

Younger patients with multiple myeloma can achieve durable survival

Younger adults with newly diagnosed multiple myeloma who receive an autologous stem cell transplant (auto-HCT) have a median progression-free survival (PFS) of approximately 3.5 years and a median overall survival (OS) of 12 years, according to a study published online June 27 in the British Journal of Haematology.

Oren Pasvolsky, M.D., from University of Texas MD Anderson Cancer Center in Houston, and colleagues performed a retrospective chart review to characterize outcomes for 117 younger patients with a median age of 37 years (range, 22 to 40 years) undergoing auto-HCT for multiple myeloma at the MD Anderson Cancer Center.

The researchers report that before transplant, 10 percent of patients achieved at least complete response (≥CR) and 44 percent achieved at least very good partial response (≥VGPR). For best posttransplant response, 56 and 77 percent achieved ≥CR and ≥VGPR, respectively. Median PFS and OS were 43.1 and 146.6 months, respectively. Compared with patients transplanted earlier, patients undergoing auto-HCT after 2010 had better median PFS (84.9 versus 28.2 months) and OS (not reached versus 91.8 months). Achieving ≥CR as best posttransplant response was associated with improved PFS (hazard ratio, 0.55); achieving ≥VGPR was predictive of superior OS (hazard ratio, 0.32).

“Younger multiple myeloma patients had durable survival after auto-HCT, which further improved after the availability of novel antimyeloma drugs in recent years,” the authors write.

More information:
Oren Pasvolsky et al, Outcomes of young adults (aged ≤ 40 years) with newly diagnosed multiple myeloma after up‐front autologous stem cell transplant, British Journal of Haematology (2023). DOI: 10.1111/bjh.18944

Copyright © 2023 HealthDay. All rights reserved.

Younger patients with multiple myeloma can achieve durable survival (2023, July 27)
retrieved 27 July 2023

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

Source link

Leave a Reply

Your email address will not be published. Required fields are marked *

Popular News Posts


Our Exclusive Products

Our Store

Our mission is simple, offer quality products that make our customers lives better at a reasonable price, while ensuring a hassle-free shopping experience. This means that before we bring a product to market, we test it to ensure that it meets our high-level quality standards. Our customer service team understand our products and can answer most every product related question quickly and efficiently. We strive everyday to meet and exceed our customers’ expectations of quality and support! Should we ever fail to meet this expectation – contact us and we will make it right!

Our Value: We are proud of our product and accomplishments, but we typically don’t shout it from the rooftop. Instead, we prefer to let our product and customers do the talking. Our core values can be recognized in our product. The qualities we strive for include:

Pragmatism: We design simple, useful solutions for common needs
Quality: From design to final product, we strive for durable solutions that work
Originality: Creativity and innovation are what makes our product unique
Design: Our minimalist and bold design language focuses on functionality and simplicity that is timeless

0 +

Top Rated Products

0 +

Happy Customers