A breakthrough in regenerative medicine

Health News
Tags :
Health News
Share This :

Bioprinting personalized tissues and organs within the body: A breakthrough in regenerative medicine
In situ bioprinting could allow for the direct synthesis of personalized tissues and organs within the body, potentially paving the future of regenerative medicine and organ transplantation. Credit: Pagan et al.

In situ bioprinting, which involves 3D printing biocompatible structures and tissues directly within the body, has seen steady progress over the past few years. In a recent study, a team of researchers developed a handheld bioprinter that addresses key limitations of previous designs, i.e., the ability to print multiple materials and control the physicochemical properties of printed tissues. This device will pave the way for a wide variety of applications in regenerative medicine, drug development and testing, and custom orthotics and prosthetics.

The emergence of regenerative medicine has resulted in substantial improvements in the lives of patients worldwide through the replacement, repair, or regeneration of damaged tissues and organs. It is a promising solution to challenges such as the lack of organ donors or transplantation-associated risks. One of the major advancements in regenerative medicine is on-site (or “in situ”) bioprinting, an extension of 3D printing technology, which is used to directly synthesize tissues and organs within the human body. It shows great potential in facilitating the repair and regeneration of defective tissues and organs.

Although significant progress has been made in this field, currently used in situ bioprinting technologies are not devoid of limitations. For instance, certain devices are only compatible with specific types of bioink, while others can only create small patches of tissue at a time. Moreover, their designs are usually complex, making them unaffordable and restricting their applications.

In a breakthrough study published in Biofabrication, a research team including Mr. Erik Pagan and Associate Professor Mohsen Akbari from the University of Victoria in Canada, developed a handheld in situ bioprinter with a convenient modular design, that allows the printing of complex biocompatible structures.

“Two decades ago, my mother was diagnosed with breast cancer, which eventually led to the removal of her breast. This affected her well-being considerably. It made me realize that a technology like handheld bioprinting could not only help develop personalized implants for breast reconstruction that match the shape and size of the patient’s tissue, but also be used to create tumor models for the study of breast cancer biology. Such applications could significantly improve treatment outcomes for affected patients,” says Prof. Akbari while discussing his motivation underlying this study.

A key feature of the handheld device is the presence of multiple bioink cartridges, each independently controlled by a pneumatic system. Owing to this, the device operator has ample control over the printing mixture, making it easier to develop structures with the required properties. Moreover, the device has a cooling module and a light emitting diode photocuring module, which provide additional control.

This versatile in situ bioprinter has several applications. Prof. Akbari elaborates, “In situ bioprinting is suitable for repairing large defects caused by trauma, surgery, or cancer, which requires large-scale tissue constructs. In the long term, this technology can eliminate the need for organ donors, while also lowering the risks associated with transplantation, allowing patients to enjoy longer and healthier lives.”

Another notable potential application of this device is the production of drug delivery systems. An operator could construct scaffolds or structures that release a precise quantity of drugs as well as cells at specific locations within the body. This would make drugs more efficient, minimize side effects associated with them, and improve their safety. The technology reported in this paper may also speed up the discovery of new drugs by allowing scientists to develop more accurate drug testing models.

What’s more, it has the potential to develop custom prosthetics and orthopedic implants. Due to its portable nature, this bioprinter may help physicians match a patient’s tissue anatomy with greater accuracy and convenience, thus enhancing the functionality and aesthetic of the bioprinted construct.

The findings of this study can significantly benefit researchers and physicians dedicated to improving the scope of regenerative medicine and enable collaborative research, which can accelerate further development of this technology.

More information:
Erik Pagan et al, A handheld bioprinter for multi-material printing of complex constructs, Biofabrication (2023). DOI: 10.1088/1758-5090/acc42c

Provided by
IOP Publishing

Bioprinting personalized tissues and organs within the body: A breakthrough in regenerative medicine (2023, June 13)
retrieved 13 June 2023
from https://medicalxpress.com/news/2023-06-bioprinting-personalized-tissues-body-breakthrough.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

Source link

Leave a Reply

Your email address will not be published. Required fields are marked *

Popular News Posts


Our Exclusive Products

Our Store

Our mission is simple, offer quality products that make our customers lives better at a reasonable price, while ensuring a hassle-free shopping experience. This means that before we bring a product to market, we test it to ensure that it meets our high-level quality standards. Our customer service team understand our products and can answer most every product related question quickly and efficiently. We strive everyday to meet and exceed our customers’ expectations of quality and support! Should we ever fail to meet this expectation – contact us and we will make it right!

Our Value: We are proud of our product and accomplishments, but we typically don’t shout it from the rooftop. Instead, we prefer to let our product and customers do the talking. Our core values can be recognized in our product. The qualities we strive for include:

Pragmatism: We design simple, useful solutions for common needs
Quality: From design to final product, we strive for durable solutions that work
Originality: Creativity and innovation are what makes our product unique
Design: Our minimalist and bold design language focuses on functionality and simplicity that is timeless

0 +

Top Rated Products

0 +

Happy Customers