11 Best Moisturizers to Use with Tretinoin Cream for Spotless And Hydrated Look

Anti-Aging Medicine
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Anti-Aging Medicine
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Written by

Sayantani Deb


Updated on Jun 08, 2023   | 


best moisturizer to use with tretinoin cream

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A good skincare regime is all we need to have flawless skin. But this isn’t easy as it looks. You may have been using topical medications like tretinoin or retinol for various skin issues. The problem is these can lead to fluctuations in the natural state of your skin. As a result, the most common symptom we see is dryness (1). Although tretinoin and retinol can effectively treat acne, scars, fine lines, etc., they can absorb your skin’s moisture and cause flakiness, especially tretinoin as it is the most concentrated and synthetic form of retinol. This is why you need the best moisturizer to use with tretinoin cream to help you restore lost moisture. 

Based on our observations, a quality hydrating moisturizer in combination with sufficient amounts of tretinoin is the key to balancing the effects of both. While moisturizers can hydrate your skin, tretinoin can reduce hyperpigmentation, acne, and pimples. 

As per our expertise, we’ve enlisted some effective moisturizers you can use with tretinoin to combat skin issues without drying it out. But before that let’s first know more about tretinoin creams. 

What Is Tretinoin Cream?

Tretinoin is a topical form of vitamin A that has anti-inflammatory properties to treat acne (1). It also works as a chemical exfoliator to remove dead skin and rejuvenate new cells. But many times, most people try using tretinoin cream without any prescription. This can cause severe skin problems such as dryness, burning, and redness, and may worsen the situation. So, it’s better to use it as per your doctor’s recommendation. Your healthcare provider can also suggest that you get yourself a good moisturizer to use with tretinoin cream to control flakiness and increase moisture retention. 

Our top picks

Best Anti-aging Formulation

11 Best Moisturizers to Use With Tretinoin Cream to Combat Dryness

The CeraVe night lotion is made with 3 essential ceramides, which can help maintain your skin’s natural barrier and reduce irritation (2). It also incorporates hyaluronic acid and niacinamide that retains skin moisture and delivers optimum hydration throughout the night (3). It’s a clinically tested moisturizer recommended for oily, sensitive, dry, and acne-prone skin. 


  • Non-comedogenic
  • Allergy tested
  • Paraben-free
  • Oil-free
  • Unscented

  • 2

    Best Creamy Formula

    belif The True Cream Aqua Bomb

    belif The True Cream Aqua Bomb

  • When it comes to managing flakiness for all skin types, this belif cream can be a great product to consider. With active ingredients such as ceramide and glycerin, it can help you get calm and radiant skin (2), (4). It’s infused with bioactive components such as squalene and lady’s mantle that control sebum and maintain skin moisture levels. It works like magic and absorbs quickly within a few seconds. Besides, it’s clinically tested to enhance hydration up to 70% and promises an improved moisture barrier within 7 days. 


    • Reduce dullness
    • Lightweight
    • No greasiness
    • Beautiful smell

  • 3

    Best for Sensitive Skin

    La Roche-Posay Toleriane Double Repair Face Moisturizer

    La Roche-Posay Toleriane Double Repair Face Moisturizer

  • The La Roche-Posay Toleriane double repair moisturizer is one of the most reliable options you can apply to balance tretinoin effects. The dermatologically tested formula repairs your skin barrier and provides a 48-hour moisture lock, all thanks to its active components — prebiotics, ceramide, and glycerin. Moreover, its oil-free, non-comedogenic formulation hydrates and restores healthy-looking skin. Our analysis of the product revealed that it works well on sensitive skin. 



    • Decrease peeling
    • Paraben-free
    • Allergy-tested
    • Fragrance-free
    • Reduces skin discoloration


    • Might have packaging defects

  • 4

    Dual Formulation

    Advanced Clinicals Retinol Firming Cream

    Advanced Clinicals Retinol Firming Cream

  • Nothing could be better than a multi-purpose formula that not only fights acne but reduces aging symptoms too. This Advanced Clinicals product is a dual-function cream that diminishes deep wrinkles, fine lines, saggy skin, and other signs of aging skin while combating acne. It’s composed of organic compounds, including chamomile, aloe vera, green tea, and glycerin, that work together to make the skin firm. With age, our skin loses elasticity and moisture, but this blend promotes collagen production to deliver perfectly radiant and youthful skin. 


    • No alcohol
    • No animal products
    • Sulfate-free
    • Long-lasting
    • Easy to use

  • 5

    Best SPF Moisturizer

    Neutrogena Rapid Wrinkle Repair Retinol Moisturizer

     Neutrogena Rapid Wrinkle Repair Retinol Moisturizer

  • Neutrogena and tretinoin can be your best friends to deal with dullness, wrinkles, acne, dark spots, and numerous other dermal issues. Formulated with retinol and avobenzone, homosalate, and other SPF components, the Neutrogena face moisturizer is clinically proven to provide clear skin in 1 week and reduce dark spots and fine lines in just 4 weeks (5), (6). Besides, it protects the skin from sun damage and prevents sunburn. Not just that, it features a combination of retinol and hyaluronic acid that add plumpness to the skin by restoring its natural moisture. 


    • Brighten’s skin tone
    • Visible results in 1 week
    • No mineral oils
    • Zero parabens

  • 6

    Most Antioxidant Rich

    Nature Theory Collagen Day & Night Anti-Aging Cream

    Nature Theory Collagen Day & Night Anti-Aging Cream

  • The 1.7oz tub of anti-aging moisturizer by Nature Theory is the complete skincare regime that you need. The cream is crafted with pure anti-oxidant-rich ingredients and is suited for all skin types. It features hyaluronic acid, hydrolyzed marine collagen, retinol, and vitamin E as the base components which enhance collagen production and improve overall skin health. The anti-aging face moisturizer supports cell renewal and restores the skin’s natural water balance to provide lustrous and youthful skin. Thus, this a great moisturizer to use with tretinoin cream to have a natural glow. 


    • Non-greasy
    • Hydrates dry skin
    • Absorbs quickly
    • Smoothen pores

  • 7

    KLEEM ORGANICS Advanced Retinol Moisturizer

    KLEEM ORGANICS Advanced Retinol Moisturizer

  • This cream is specifically made for neck and décolleté. For those who are frustrated with a saggy neck and double chin, this Kleem Organic product is the ultimate solution. It’s a perfect fusion of organic components- retinol, vitamins, and collagen that tightens neck skin, decreases wrinkles, and lifts the jawline. In addition, the cream eliminates signs of aging and nourishes skin cells resulting in a firmer, younger, and more attractive neck. Our research indicates that applying this blend twice a day with gentle massages derives faster and more effective results. 



    • Penetrates quickly
    • GMO-free
    • Allergy tested
    • No artificial colors
    • Cruelty-free

  • 8

    Best Botanical Blend

    LilyAna Naturals Retinol Cream

    LilyAna Naturals Retinol Cream

  • Bless your skin with LilyAna Naturals cream after a long tiring day. This lightweight formula is filled with the goodness of botanicals like green tea, jojoba oil, shea butter, etc., that feed your dermis and add moisture. It’s a balanced blend of wrinkle-fighting and anti-aging activities. Use it twice a day to reveal your original complexion and have naturally alluring skin. Furthermore, the vitamin A-containing cream minimizes acne scars, redness, and uneven skin texture and tone, so you can appreciate your true beauty. 



    • Zero residue
    • Smooth texture
    • Minimize sun spots
    • Non-comedogenic


    • May cause breakouts (dermatologist’s recommendation needed)

  • 9

    Best Anti-aging Formulation

    Medix 5.5 Retinol + Ferulic Acid Body Treatment Cream

     Medix 5.5 Retinol + Ferulic Acid Body Treatment Cream

  • Sagginess, aging, wrinkles, spots, and other skin disorders are our skin’s inevitable enemies. But the Medix 5.5 Retinol Body Lotion can solve our skin problems. This lotion is a scientific blend of plant extracts like ferulic acid with vitamin E, green tea, chamomile, retinol, etc., that decreases visible redness and irritation and increases luminosity and plumpness (7). Also, the mixture defends your skin against environmental stress factors like pollution that cause acne, pore-clogging, blackheads, etc. 



    • Clinically tested
    • Softens skin texture
    • Age reversing formula
    • Non-irritating
    • Antioxidant-rich

  • 10

    Best for Pigmentation

    Bella Beauty Retinol Cream Moisturizer

    Bella Beauty Retinol Cream Moisturizer

  • This Bella Beauty product is one of a kind formula that possesses 2.5% active retinol with green tea, hyaluronic acid, vitamin E, and other organic compounds that decrease hyperpigmentation and wrinkles. It allows the skin to regain its elasticity that may have been reduced due to dermal diseases, UV exposure, or bad lifestyle habits. Besides, the blend is rich in antioxidants and activates collagen to minimize fine lines and boost skin tone. With improved skin firmness and zero pigmentation, you can feel confident all day long.


    • All-natural
    • Cruelty-free
    • Vegan
    • For all skin types

  • 11


    Ebanel 2.5% Retinol Moisturizer Cream

    Ebanel 2.5% Retinol Moisturizer Cream

  • The retinol cream works at the molecular level to deeply treat skin cells and show better results. The 3.5 Fl Oz bottle is an effective treatment for pimples, cysts, blackheads, breakouts, and aging signs. Enriched with retinol, peptides, vitamins, etc., this face cream acts as a skin rejuvenator and wrinkle filler, especially in the forehead, face, and under-eye areas. It’s also an exfoliator that gently resurfaces dull skin and fastens skin turnover. Use it consistently to get desired results.



    • Rose smell
    • Vegan-friendly
    • GMP Certified
    • Fades age spots


    • Might not be suitable for hypersensitive skin

    Now that you’ve gone through our recommendations for the best moisturizers to use with tretinoin cream, we suggest you check our buying guide for a better understanding before picking one. 


    How to Pick the Best Moisturizer to Use With Tretinoin Cream?

    For this, go through the factors below:

    Ditch moisturizers with harsh chemicals, sulfates, parabens, benzoyl peroxide, salicylic acid, etc. Use gentle moisturizers with ingredients like ceramides, glycerin, botanicals, etc. 

    • Allergy-tested formulations 

    It’s good to pick allergy-tested or hypoallergenic formulations to prevent reactions, especially when you have sensitive skin. For acne-prone skin, the formula should also be non-comedogenic so it doesn’t cause breakouts. 

    As you’re a tretinoin user, your skin is sensitive to sun exposure and UV radiation. So choose one with suitable SPF levels. 

    • Professional Recommendation

    Never hesitate to consult your doctor in case of doubts. This will reduce the chances of causing side effects. 

    Now that you’ve understood how to choose the best moisturizer to use with tretinoin cream, let’s know how to apply one. 

    How to Use Moisturizer with Tretinoin Cream?

    Using a moisturizer to use with tretinoin is a 3-step process. 

    1. Apply the cream and wait for at least 20-30 minutes. 
    2. Apply the moisturizer in a specific quantity as recommended by your doctor. 
    3. Let it set properly, and wipe it off with a gentle cleanser after a few hours. 

    Tretinoin exhibits numerous skin benefits right from treating acne to repairing sun-damaged skin. But it can induce dryness and flakiness if not used accurately. However, moisturizers always come in handy to neutralize the “dryness effect” of tretinoin. But this doesn’t mean you can use any moisturizer that isn’t relevant to your skincare goals. Doing so can only cause problems. Thus, you must check for the factors like ingredients, allergy severity, etc., before buying or applying a moisturizer with tretinoin cream. And do consider an expert’s recommendation in case of any doubts or complications. 



    1. Tretinoin


    2. Ceramides and skin function


    3. Efficacy Evaluation of a Topical Hyaluronic Acid Serum in Facial Photoaging


    4. Glycerol Improves Skin Lesion Development in the Imiquimod Mouse Model of Psoriasis: Experimental Confirmation of Anecdotal Reports from Patients with Psoriasis


    5. Avobenzone


    6. Homosalate


    7. Ferulic Acid: Therapeutic Potential Through Its Antioxidant Property


    Author BIO

    Sayantani is a certified hair and makeup professional turned writer with 2+ years of experience in the same genre. Ap More


    What to avoid when using tretinoin?

    During the initial 6 months, avoid exposure to extreme wind, sunlight, or cold weather. Your skin may experience dryness, irritation, or sunburn for the first 2 or 3 weeks, but you can support the treatment with a nourishing moisturizer.

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