Thesis explores prognosis of nasopharyngeal carcinoma

Health News
Tags :
Health News
Share This :


Prognosis of nasopharyngeal carcinoma
Credit: Sisi Huang and Yun Du

Nasopharyngeal carcinoma (NPC) is a type of cancer that occurs in the nasopharynx, which is located behind the nose and above the back of the throat. NPC has a geographically skewed distribution worldwide, with high incidence rates in East and Southeast Asia. NPC is difficult to detect early, and treatment usually involves radiation therapy, chemotherapy or a combination of the two.

Recent hospital-based studies suggest that the development of new radiotherapy techniques has contributed to improved NPC prognosis, but little population-based research on NPC patient survival is available. Similarly, little is known about potential environmental prognostic factors for NPC, such as body mass index (BMI) and body shape, pretreatment plasma Epstein-Barr virus (EBV) DNA, and oral microbiome. Therefore, Ph.D. student Yun Du at the Department of Medical Epidemiology and Biostatistics aimed her doctoral thesis to characterize population-based NPC survival patterns and identify potential prognostic factors for NPC in southern China.

What are the most important results in your thesis?

By using a population-based patient cohort of NPCGEE project in southern China, we estimated five-year survival rates and investigated potential environmental prognostic factors. We also found that population-based NPC survival lags behind large-hospital-based survival. Overweight at diagnosis indicated a favorable long-term prognosis, whereas a thinner body shape at diagnosis was associated with worse prognosis. Pretreatment plasma EBV DNA was found to be a strong prognostic factor for NPC and decreased within-community diversity in oral microbiome was related to increased mortality. Taken together, this is the first population-based evidence on NPC prognosis in southern China with almost complete follow-up, and points to potential routes to improving NPC management and long-term outcomes in this NPC-endemic region.

Can your findings be generalized?

This thesis was conducted in a NPC-endemic area where most of the cases from the studied population were enrolled during the study period. Hence, the findings of our study have high external validity and may be applied to a broader population in southern China or other endemic areas.

What do you think should be done in future research for these patients?

We found that approximately one-fifth of deaths could have been avoided if all cases had been diagnosed at an early stage. These results motivate us to further explore early detection methods for NPC. Second, we could explore the reasonable clinical practice to corporate nutrition management and plasma EBV DNA into NPC treatment. For the microbiome research, we have lots of unknown prospective, for instance, the underlying mechanism, the role of immunity and immunotherapy etc., for us to explore deeper.

More information:
Prognosis of nasopharyngeal carcinoma: body mass index, plasma Epstein-Barr virus DNA and oral microbiome. hdl.handle.net/10616/48643

Citation:
Thesis explores prognosis of nasopharyngeal carcinoma (2023, June 7)
retrieved 7 June 2023
from https://medicalxpress.com/news/2023-06-thesis-explores-prognosis-nasopharyngeal-carcinoma.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.





Source link

Leave a Reply

Your email address will not be published. Required fields are marked *

Popular News Posts

Categories

Our Exclusive Products

Our Store

Our mission is simple, offer quality products that make our customers lives better at a reasonable price, while ensuring a hassle-free shopping experience. This means that before we bring a product to market, we test it to ensure that it meets our high-level quality standards. Our customer service team understand our products and can answer most every product related question quickly and efficiently. We strive everyday to meet and exceed our customers’ expectations of quality and support! Should we ever fail to meet this expectation – contact us and we will make it right!

Our Value: We are proud of our product and accomplishments, but we typically don’t shout it from the rooftop. Instead, we prefer to let our product and customers do the talking. Our core values can be recognized in our product. The qualities we strive for include:

Pragmatism: We design simple, useful solutions for common needs
Quality: From design to final product, we strive for durable solutions that work
Originality: Creativity and innovation are what makes our product unique
Design: Our minimalist and bold design language focuses on functionality and simplicity that is timeless

0 +

Top Rated Products

0 +

Happy Customers